Mangosteen fruit is cultivated in the tropical rainforest of some Southeast Asian nations like Indonesia, Malaysia, Sri Lanka, Philippines, and Thailand. People in these countries have used the pericarp (peel, rind, hull or ripe) of GML as a traditional medicine for the treatment of abdominal pain, diarrhea, dysentery, infected wound, suppuration, and chronic ulcer.

Experimental studies have demonstrated that mangosteen extracts have antioxidant, antitumoral, antiallergic, anti-inflammatory, antibacterial, and antiviral activities.

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